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Orforglipron - GLP-1 - 9mg x 60 Capsules
Orforglipron - GLP-1 - 9mg x 60 Capsules
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Orforglipron is an experimental, oral, daily GLP-1 receptor agonist. Phase 3 trials have shown it effectively lowers blood sugar and promotes significant weight loss, with the safety profile being consistent with other GLP-1 drugs but with a higher incidence of mild-to-moderate gastrointestinal side effects like nausea and diarrhea, particularly during dose escalation.
Efficacy:
Weight loss:
Orforglipron demonstrated superior weight reduction compared to placebo in obese patients, with one study showing an average loss of up to 12.4% at the highest dose.
Blood sugar control:
It significantly lowered A1c levels in patients with type 2 diabetes, both as monotherapy and when used with insulin.
Other benefits:
Studies also reported improvements in fasting serum glucose, systolic blood pressure, and certain cholesterol levels.Side effects.
Gastrointestinal issues:
The most common side effects are mild to moderate gastrointestinal issues like nausea, diarrhea, vomiting, and constipation.
Dose-dependent:
These side effects are often more pronounced during the initial period of dose escalation.
Serious adverse events:
The proportion of participants experiencing serious adverse events did not differ between orforglipron and placebo groups in a specific trial.
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